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Deadly Dish: The Dinner That Can Give You Cancer

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A local delicacy in north-east Thailand, made from raw fish, has been found to be behind a high incidence of liver cancer in the area, and doctors are trying to educate people about the risk.


The Isaan plateau of north-eastern Thailand is poor, dry, and far from the sea. Home to around one third of the country's population, most of them ethnic Lao in origin, it is renowned for its spicy and inventive cuisine, using whatever ingredients are available.


Where there are rivers or lakes, they use the smaller fish they catch in a pungent dish called koi plaa. The fish are chopped up finely, and mixed by hand with local herbs, lime juice and live red ants, and served up raw.


It is very popular, but also dangerous.


For decades, certain populations in the north-east have been known to have abnormally high levels of liver cancer.


In men it comprises more than half of all cancer cases, compared to an average of less than 10% worldwide.


The high prevalence has long been linked to infection by liver flukes, a kind of parasite, found in raw fish.


But it is only in the last decade that a serious effort has been made to get people to change their eating habits, by cooking koi plaa to kill the flukes before they eat it.


Dr. Banchob Sripa at the Tropical Disease Research Laboratory in Khon Kaen University is the man largely responsible for this effort.


"We have been studying this link in our labs for over 30 years", he said.


"We found that the liver fluke can make a chemical that stimulates a host immune response - inflammation - and after many years, this becomes chronic inflammation, which then becomes cancer."


His team found that in some communities up to 80% of people were inflected by the fluke, some as young as four years-old, but that the cancer rarely developed before people reached 50. Once it does, though, there is little hope for patients.


At the university hospital they receive around 2,000 patients a year with a specific form of liver cancer called cholangiocarcinoma.


Only around 200 of those can be treated, usually by surgery, cutting out the tumour from the liver.


The others are given palliative care, easing their discomfort, usually by draining bile ducts, until they die.


The only effective remedy is prevention.


So Dr. Banchob and his team are running a community-based health education programme in the villages along the great wetland, known as Lawa Lake, south of Khon Kaen, where liver fluke infection rates are highest.


They started by using the most effective methods for this region; recruiting respected community leaders to do most of the talking, and injecting plenty of north-eastern music and humour, which can be as pungent as the local cooking.


They have composed songs that press home easily understood information about the life-cycle of the fluke.


The larvae, embedded in the fish's flesh, are consumed and grow into an adult flukes inside the liver.


The eggs are then excreted, passing back into the water system where they are eaten by a particular snail, before the larvae move back to the fish again.


They also take a portable ultrasound machine around the villages to screen people for liver fluke infection.

It is striking how many older people have high levels, indicating that they still eat their koi plaa raw.


"Sometimes I cook it, but sometimes I forget," said 61-year-old Jongluck Laonongkwa after his screening. His liver was infested with flukes.


"I think 60% do understand the causes of the liver cancer" said Dr. Banchob, "they are aware of the liver fluke.


"But 10% are still eating raw fish. I believe that 10% probably cannot change. So we should change the environment, make the fish cleaner, to get fewer infections."


Part of the education campaign focuses on getting people to use proper toilets, and not defecate in the lake, which reduces the number of fluke eggs.


In the villages where the campaign has been running, infection rates are coming down sharply, to below 10% in some.


It will take more time for liver cancer rates to fall significantly, but the attitude of younger people is encouraging.


Kamphan Sapsombat, 71, is being treated in hospital for an inoperable tumour. He is jaundiced, with yellow eyes which is a clear sign of a blocked bile duct.


His daughter, Rattana, said her father had eaten raw fish all his life. But the rest of her family had stopped it years ago, she said.


They understood all too well that the risk of ending up like her father was not worth it.




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For the first time ever, recently, I had food poisoning from eating some seafood. It didn't go away and the pain in stomach just got worse. So off to the pharmacy for some medication to clear it up, but the discomfort continued. I'm not one to see a doctor and would do everything to avoid, but the boyfriend insisted we had to go to the hospital, and along with the pain had no choice. On arrival at the door I was put into a wheelchair and taken to emergency. Almost straight away, a doctor examined me and confirmed acute food poisoning and administered an injection, and was left for 20 minutes for injection to take effect.


The boyfriend was taken back in the speed and the attention of it all. Saying in a UK hospital you would be lucky to even get to see a doctor in less than 6 hours. Anyway, the injection worked and 30 minutes later I was leaving the hospital. What have I learnt, our doctors and hospitals are certainly as good if not better than elsewhere in the world.

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